COVID-19 Related Myocarditis: Diagnosis and Management

COVID-19 Related Myocarditis


  • Antonis S Manolis First Department of Cardiology, Athens University School of Medicine, Athens, Greece
  • Theodora A Manolis Athens University School of Medicine


A comprehensive review of current data on COVID-19 related myocarditis is herein presented. Rhythmos 2022;17(2): 25-31.


De Lorenzo A, Kasal DA, Tura BR, Lamas CC, Rey HC. Acute cardiac injury in patients with COVID-19. Am J Cardiovasc Dis 2020;10:28-33.

Bavishi C, Bonow RO, Trivedi V, et al. Acute myocardial injury in patients hospitalized with COVID-19 infection: A review. Prog Cardiovasc Dis 2020;63:682-89.

Ho JS, Sia CH, Chan MY, Lin W, Wong RC. Coronavirus-induced myocarditis: A meta-summary of cases. Heart Lung 2020;49:681-85.

Manolis AS, Manolis AA, Manolis TA, Melita H. COVID-19 and acute myocardial injury and infarction: Related mechanisms and emerging challenges. J Cardiovasc Pharmacol Ther 2021;26:399-414.

Imazio M, Klingel K, Kindermann I, et al. COVID-19 pandemic and troponin: indirect myocardial injury, myocardial inflammation or myocarditis? Heart 2020;106:1127-31.

Sandoval Y, Januzzi JL, Jr., Jaffe AS. Cardiac Troponin for the Diagnosis and Risk-Stratification of Myocardial Injury in COVID-19. J Am Coll Cardiol 2020;76:1244-58.

Manolis AS, Manolis TA. Cardiovascular complications of the coronavirus (COVID-19) infection. Rhythmos 2020;15:23-28.

Manolis AS, Manolis TA, Manolis AA, Melita H. Cardiovascular implications and complications of the coronavirus disease-2019 pandemic: a world upside down. Curr Opin Cardiol 2021;36:241-51.

Manolis AS, Manolis TA, Manolis AA, Papatheou D, Melita H. COVID-19 infection: Viral macro- and micro-vascular coagulopathy and thromboembolism/Prophylactic & therapeutic management. J Cardiovasc Pharmacol Ther 2021;26:12-24.

Manolis AS, Manolis AA, Manolis TA, Melita H. Acute coronary syndromes in patients with angiographically normal or near normal (non-obstructive) coronary arteries. Trends Cardiovasc Med 2018;28:541-51.

Gluckman TJ, Bhave NM, Allen LA, et al. 2022 ACC Expert Consensus Decision Pathway on cardiovascular sequelae of COVID-19 in adults: Myocarditis and other myocardial involvement, post-acute sequelae of SARS-CoV-2 infection, and return to play: A report of the ACC Solution Set Oversight Committee. J Am Coll Cardiol 2022 Mar 14;S0735-1097(22)00306-0. doi: 10.1016/j.jacc.2022.02.003. Online ahead of print.

Beşler MS, Arslan H. Acute myocarditis associated with COVID-19 infection. Am J Emerg Med 2020;38:2489.e1-89.e2.

Gravinay P, Issa N, Girard D, Camou F, Cochet H. CMR and serology to diagnose COVID-19 infection with primary cardiac involvement. Eur Heart J Cardiovasc Imaging 2021;22:133.

Wenzel P, Kopp S, Göbel S, et al. Evidence of SARS-CoV-2 mRNA in endomyocardial biopsies of patients with clinically suspected myocarditis tested negative for COVID-19 in nasopharyngeal swab. Cardiovasc Res 2020;116:1661-63.

Tavazzi G, Pellegrini C, Maurelli M, et al. Myocardial localization of coronavirus in COVID-19 cardiogenic shock. Eur J Heart Fail 2020;22:911-15.

Li JW, Han TW, Woodward M, et al. The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis. Prog Cardiovasc Dis 2020;63:518-24.

Tersalvi G, Vicenzi M, Calabretta D, et al. Elevated troponin in patients with COVID-19: Possible mechanisms. J Card Fail 2020;26:470-75.

Wei X, Fang Y, Hu H. Immune-mediated mechanism in coronavirus fulminant myocarditis. Eur Heart J 2020;41:1855.

Dare RK. Is fulminant myocarditis caused by circulating human coronaviruses? Eur Heart J 2020;41:1854.

Luetkens JA, Isaak A, Zimmer S, et al. Diffuse myocardial inflammation in COVID-19 associated myocarditis detected by multiparametric CMR imaging. Circ Cardiovasc Imaging 2020;13:e010897.

Craver R, Huber S, Sandomirsky M, et al. Fatal Eosinophilic Myocarditis in a Healthy 17-Year-Old Male with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2c). Fetal Pediatr Pathol 2020;39:263-68.

Gnecchi M, Moretti F, Bassi EM, et al. Myocarditis in a 16-year-old boy positive for SARS-CoV-2. Lancet 2020;395:e116.

Hékimian G, Kerneis M, Zeitouni M, et al. Coronavirus Disease 2019 acute myocarditis and multisystem inflammatory syndrome in adult ICUs. Chest 2021;159:657-62.

Grimaud M, Starck J, Levy M, et al. Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. Ann Intensive Care 2020;10:69.

Kariyanna PT, Sutarjono B, Grewal E, et al. A Systematic Review of COVID-19 and Myocarditis. Am J Med Case Rep 2020;8:299-305.

Sawalha K, Abozenah M, Kadado AJ, et al. Systematic review of COVID-19 related myocarditis: Insights on management and outcome. Cardiovasc Revasc Med 2021;23:107-13.



2022-04-04 — Updated on 2022-04-04