Novel Angiography-Derived Techniques for Functional Assessment of Coronary Artery Disease
Functional Assessment of Coronary Artery Disease
Abstract
Background: The importance of coronary physiology in identifying hemodynamically significant lesions is well established.
Objective: The current review summarizes the most important studies of the novel techniques developed over the last decade that allow the computation of fractional flow reserve (FFR) from either invasive or computed coronary angiography.
Methods: A systematic review of all published research in PubMed and Google Scholar databases, regarding the angiography-derived functional assessment of coronary artery disease (CAD) has been performed. The following terms were used: “functional angiography”, “quantitative flow ratio”, “computed tomography-derived FFR”, “FFR angiography” and “virtual FFR”.
Results: Several multicenter clinical trials have presented the currently available techniques for physiological assessment of coronary artery stenosis, such as quantitative flow ratio (QFR), computed tomography-derived FFR, FFRangio and virtual FFR, their theoretical basis and methodology, as well as their diagnostic performance, using invasive FFR as reference standard.
Conclusion: A variety of novel angiography-derived techniques for physiological assessment of CAD exist, showing high diagnostic performance and are expected to increase the use of coronary physiology in the guidance of clinical decision making upon revascularization strategy. Rhythmos 2020;15(4):73-77.
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