Cardiology News / Recent Literature Review / First Quarter 2022
ACC.22, Washington, DC, USA, 2-4/4/22
EHRA 22, Copenhagen, Denmark, 3-5/4/22
HRS 22, San Francisco, CA, USA, 29/4-1/5/22
EuroPCR, Paris, France, 17-20/5/22
ESC Meeting, Barcelona, Spain, 26-29/8/2022
TCT 22, Boston, MA, USA, 16-20/9/22
PRAGUE-17: Left Atrial Appendage Closure (LAAC) Remains Noninferior to DOACs for Preventing Major CV, Neurological, or Bleeding Events / Nonprocedural Bleeding Was Significantly Reduced With LAAC
A total of 402 patients with AF (201 per group, age 73.3±7.0 years, 65.7% male, CHA2DS2-VASc 4.7±1.5, HASBLED 3.1±0.9) were randomized to percutaneous LAAC (Watchman or Amulet) with DOACs (95% apixaban). After a median of 3.5 years, LAAC was noninferior to DOACs for the primary endpoint (composite of cardioembolic events-i.e., stroke, TIA, or systemic embolism-, CV death, clinically relevant bleeding, or procedure-/device-related complications (LAAC group only)), by modified intention-to-treat (sub-distribution HR [sHR]: 0.81; P = 0.27; P for noninferiority = 0.006). For the components of the composite endpoint the corresponding sHRs were 0.68 (P= 0.19) for CV death, 1.14 (P=0.72) for all-stroke/TIA, 0.75 (P=0.28) for clinically relevant bleeding, and 0.55 (P=0.039) for nonprocedural clinically relevant bleeding. The primary endpoint outcomes were similar in the per-protocol (sHR: 0.80; P=0.25) and on-treatment (sHR: 0.82; P=0.30) analyses (Osmancik P et al, J Am Coll Cardiol 2022;79:1-14).
Higher Olive Oil Intake Conferred Lower Risk of Total and Cause-Specific Mortality / Replacing Margarine, Butter, Mayonnaise, and Dairy Fat with Olive Oil Lowered Mortality
Among 60,582 women (Nurses’ Health Study, 1990-2018) and 31,801 men (Health Professionals Follow-up Study, 1990-2018) who were free of cardiovascular (CV) disease or cancer, over 28 years, 36,856 deaths occurred. The multivariable-adjusted pooled HR for all-cause mortality among persons who had the highest consumption of olive oil (>0.5 tablespoon/day or >7 g/d) was 0.81 compared with those who never or rarely consumed olive oil. Higher olive oil intake conferred a 19% lower risk of CV mortality (HR: 0.81), 17% lower risk of cancer mortality (HR: 0.83), 29% lower risk of neurodegenerative disease mortality (HR: 0.71), and 18% lower risk of respiratory disease mortality (HR: 0.82). In substitution analyses, replacing 10 g/d of margarine, butter, mayonnaise, and dairy fat with the equivalent amount of olive oil conferred 8%-34% lower risk of total and cause-specific mortality. No significant associations were observed when olive oil was compared with other vegetable oils combined (Guasch-Ferré M et al, J Am Coll Cardiol 2022;79:101–112)... (excerpt)
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