Insights into the Clinical Spectrum of Catecholaminergic Polymorphic Ventricular Tachycardia
Keywords:
catecholaminergic polymorphic ventricular tachycardia, sudden cardiac death, genetic testing, channelopathiesAbstract
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is induced by stress or exertion especially in young individuals with normal baseline ECG and without any structural heart disease. The most common type of ventricular tachycardia (VT) in these patients is bidirectional VT but could also be polymorphic VT or ventricular fibrillation. These two main types of CPVT are caused by mutations on the ryanodine (RyR2) or calsequestrin (CASQ2) receptor, with an autosomal dominant and recessive inheritance pattern respectively. The prognosis is dismal without treatment and the main therapeutic approach consists of administration of beta blocker, flecainide, calcium channel blockers or ICD implantation. Genetic testing is important for all family members of CPVT probands in order to identify asymptomatic carriers. Rhythmos 2018;13(1):6-8.
Downloads
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
