Cardiology News /Recent Literature Review / Last Quarter 2011

Authors

  • Antonis S Manolis Athens University School of Medicine & First Department of Cardiology, Evagelismos General Hospital of Athens, Athens, Greece
  • Hector Anninos Evagelismos Hospital, Athens

Keywords:

cardiology, electrophysiology, cardiac pacing, news

Abstract

The ACC Meeting is slated for 24-27/3/2012 in Chicago

 The Athens Cardiology Update 2012 is slated for April 5-7, 2012

 The HRS 33rd Meeting will be held in Boston, 9-12/5/12

 The ESC Congress will be held in Munich, 25-29/8/2012

 ALLHAT Trial: Once Heart Failure Develops in High-Risk Hypertensive Patients, Mortality is High

At a mean follow-up of 8.9 years, of 1761 participants in the ALLHAT trial with incident heart failure (HF) in-trial, 1348 (77%) died. Mortality rates were similar across treatment comparisons, with adjusted 10-year all-cause mortality rates per 100 persons of 83 for chlorthalidone, 86 for amlodipine, and 87 for lisinopril. Mortality was similar for those with preserved (81%) and low ejection fraction (84%). Thus, once HF develops, risk of death is high and consistent across randomized treatment groups. Measures to prevent the development of HF, especially blood pressure control, must be a priority if mortality associated with the development of HF is to be addressed (Piller LB et al, Circulation 2011;124:1811-1818).

 Isolated Low HDL-Cholesterol is Associated with Increased Coronary Risk

Data from 220 060 participants (87% Asian) in 37 studies from the Asia-Pacific region indicated low HDL-C (HDL <40 mg/dl in men and <50 mg/dl in women) among 33.1% of Asians vs 27.0% of non-Asians (P<0.001). The prevalence of low HDL-C in the absence of other lipid abnormalities (isolated low HDL-C) was higher in Asians compared with non-Asians: 22.4% vs 14.5%, respectively (P<0.001). After 6.8 years, there were 574 coronary heart disease and 739 stroke events. There was an inverse relationship between low HDL-C with coronary heart disease in all individuals (hazard ratio, 1.57). In Asians, isolated low levels of HDL-C were as strongly associated with coronary heart disease risk as low levels of HDL-C combined with other lipid abnormalities (hazard ratio, 1.67 vs 1.63, respectively). There was no association between low HDL-C and stroke risk (Huxley RR et al, Circulation2011;124:2056-2064)... (excerpt)

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Published

2012-01-01

Issue

Vol. 7 No. 1 (2012)

Section

Cardiology News

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