Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-Cov-2 Infection (PIMS-TS): Kawasaki-Like Multisystem Inflammatory Syndrome in Children (MIS-C) During the COVID-19 Pandemic with Predominant Myocarditis
Kawasaki-Like Multisystem Inflammatory Syndrome in Children (MIS-C) During the COVID-19 Pandemic
Abstract
During the COVID-19 pandemic, a Kawasaki-like multisystem inflammatory syndrome with predominant myocarditis associated with SARS-CoV-2 infection has recently been reported, now referred to as Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19, or Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 infection (PIMS-TS). These pediatric patients present with features that overlap features of Kawasaki Disease (KD) and toxic shock syndrome, albeit with distinct differences that relate to more common myocardial involvement requiring vasopressor support in PIMS-TS/MIS-C compared to KD (~50% vs ~5%), and less common coronary artery aneurysms (~9% vs ~25%). PIMS-TS/MIS-C seems to be largely immune-mediated, triggered by COVID-19, with the induced hyperinflammatory syndrome possibly due to post-infectious cytokine storm, rather than a result of direct cell injury caused by the virus. Treatment of this syndrome is similar to KD and includes intravenous immunoglobulin (IVIG), corticosteroids, and antiplatelet agents, while a few patients have also received interleukin-6 (IL-6) inhibitors. Rhythmos 2020;15(3):42-46.
Downloads
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
